Drug Assessments

The Drug Assessment Working Group (DAWG) is committed to analyze scientific evidence on the effectiveness and safety of drug therapies used in Canada. They systematically review and, when appropriate, critically appraise research relevant to new and existing drugs. Often the goal is to discover whether a new drug provides a therapeutic advantage over existing similar drug therapy for a clinical condition. The Therapeutics Initiative has a dedicated team of researchers that is committed to the highest standards of research. In addition to reports on various new and existing drugs (see list below for links to executive summaries), the DAWG also contributes to the federal Common Drug Review (CDR), a national program set up to reduce duplication, and provide equal access to high level evidence and expert advice, thereby contributing to the quality and sustainability of Canadian public drug plans. The DAWG has contributed to many of the CDR reviews. Click here to search the CDR Drug Database, with links to the executive summaries and recommendations.

Below is a list of completed DAWG reports with links to the executive summaries.

Post Datesort icon Topic
Jun 28, 2010 Ganciclovir and valganciclovir for the preemptive treatment of CMV in adult patients who have undergone allogeneic stem cell transplantation View
Apr 30, 2010 Peginterferon alfa-2a (Pegasys) for the treatment of adult patients with chronic hepatitis B View
Apr 23, 2010 OROS methylphenidate (Concerta) for the treatment of children and adults with ADHD View
Apr 23, 2010 Clindamycin phosphate 2% vaginal cream (Clindesse) for the treatment of bacterial vaginosis View
Apr 22, 2009 Clopidogrel for the treatment of adult patients following acute coronary syndrome View
Mar 17, 2009 Rituximab for the treatment of rheumatoid arthritis View
Mar 6, 2009 Imiquimod cream for the treatment of adult patients with actinic keratosis View
Mar 6, 2009 Calcipotriol/betamethasone (Dovobet) ointment for the treatment of adult patients with psoriasis vulgaris View
Mar 6, 2009 Dalteparin for extended treatment of symptomatic venous thromboembolism in patients with cancer View
Feb 20, 2009 Ethinyl estradiol 30 µg and levonorgestrel 150 µg (Seasonale) for prevention of pregnancy View
Feb 17, 2009 Imiquimod cream for actinic keratosis View
Feb 17, 2009 Calcipotriol/betamethasone dipropionate (Dovobet) ointment for the treatment of adult patients with psoriasis vulgaris View
Nov 13, 2008 Olanzapine for Maintenance Therapy View
Nov 12, 2008 Moxifloxacin for acute exacerbations of chronic bronchitis View
Nov 12, 2008 Moxifloxacin for community acquired pneumonia View
Nov 12, 2008 Levofloxacin for community acquired pneumonia View
Nov 12, 2008 Levofloxacin for acute exacerbations of chronic bronchitis View
Oct 17, 2008 Mesalamine for induction of remission in patients with active mild to moderate ulcerative colitis View
Oct 17, 2008 Moxifloxacin for acute bacterial sinusitis View
Oct 17, 2008 Levofloxacin for acute bacterial sinusitis View
Aug 27, 2008 Olanzapine for the treatment of adult patients with acute mania View
Aug 20, 2008 Somatropin (Nutropin) for patients with adult growth hormone deficiency View
Feb 4, 2008 Ezetimibe for the treatment of adult patients with hypercholesterolemia View
Feb 4, 2008 Nimesulide must be withdrawn worldwide due to serious liver damage View
Dec 19, 2007 Clopidogrel after drug-eluting stent implantation View
Dec 11, 2007 Oral delta-9-THC (Marinol) for AIDS-related anorexia/weight loss View
Oct 22, 2007 Low molecular weight heparins for secondary prevention of symptomatic venous thromboembolism in patients with cancer View
Oct 22, 2007 Bosentan for the treatment of pulmonary arterial hypertension associated with congenital heart disease View
Oct 10, 2007 Gliclazide for Type 2 Diabetes mellitus View
Jun 6, 2007 Interferon beta-1b for clinically isolated syndrome (multiple sclerosis) View
Jun 6, 2007 Dalteparin for extended treatment of symptomatic venous thromboembolism in patients with cancer (last update: April 2008) View
Jun 6, 2007 Insulin aspart for diabetes mellitus (last update: March 2007) View
Jun 5, 2007 Insulin lispro for diabetes mellitus (last update: March 2007) View