Drug Assessments from the Therapeutics Initiative's research

Ganciclovir and valganciclovir for the preemptive treatment of CMV in adult patients who have undergone allogeneic stem cell transplantation

Introduction

Pharmaceutical Services Division requested a systematic review of intravenous ganciclovir and oral valganciclovir for preemptive therapy of cytomegalovirus (CMV) infection in allogeneic stem cell transplant patients.

Drug

Ganciclovir is indicated for treatment of CMV retinitis in immuno-compromised patient and prevention of CMV disease in transplant recipients.  It inhibits viral DNA synthesis by interfering with DNA incorporation and termination of DNA elongation. 

Peginterferon alfa-2a (Pegasys) for the treatment of adult patients with chronic hepatitis B

Introduction

Pharmaceutical Services Division requested an updated systematic review of peginterferon alfa-2a (Pegasys) for the treatment of chronic hepatitis B, previously reviewed by the Therapeutics Initiative in November 2006.

Drug

Peginterferon alfa-2a injection (Pegasys) is categorized as an anti-viral compound and as a biological response modifier. The recommended dose is 180μg once weekly for 48 weeks by subcutaneous administration in the abdomen or thigh.

OROS methylphenidate (Concerta) for the treatment of children and adults with ADHD

Introduction

Pharmaceutical Services Division (PSD) requested an update to the 2006 Therapeutics Initiative review of Concerta (OROS MPH) for the treatment of children and adults with ADHD. The 2006 report included a systematic review in children and adolescents with ADHD. The recent submission includes additional new information in children and adolescents and also an additional new indication, for the treatment of adult patients with ADHD.

Clindamycin phosphate 2% vaginal cream (Clindesse) for the treatment of bacterial vaginosis

Introduction

Pharmaceutical Services Division (PSD) requested a systematic review of Clindesse for the treatment of non-pregnant women ≥ 18 years of age with bacterial vaginosis.

Drug

Clindesse is a semi-solid white cream containing 2% clindamycin phosphate, which is a water-soluble ester of the semi-synthetic antibiotic produced by a 7 (S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic, lincomycea. The recommended dose is a single intravaginal administration on one day.

Clopidogrel for the treatment of adult patients following acute coronary syndrome

Introduction: this is an update of the November 2004 Therapeutics Initiative systematic review report.
Research questions:

Rituximab for the treatment of rheumatoid arthritis

Introduction: This report is an updated systematic review of rituximab done by CDR in November 2006 and also attempts to answer the 2 research questions stated below.

Imiquimod cream for actinic keratosis

This is the summary of an update of the February 2005 Therapeutics Initiative systematic review of imiquimod 5% cream (Aldara) for the treatment of actinic keratosis.

Calcipotriol/betamethasone dipropionate (Dovobet) ointment for the treatment of adult patients with psoriasis vulgaris

This is a summary of a systematic review of calcipotriol/betamethasone dipropionate (Dovobet) ointment in the treatment of adult patients with psoriasis vulgaris.

Moxifloxacin for community acquired pneumonia

Background Information of the Condition

Pneumonia is the leading cause of death from infection, particularly among elderly and hospitalized patients.1 Diagnosis is based on history, co-morbidities, physical findings, and a chest x-ray. S. pneumoniae accounts for up to 50% of community-acquired pneumonia caused by bacteria.2

Drug (Product Monograph)3, 4

Category: Moxifloxacin is a member of the fluoroquinolone class of antibiotics.

Clopidogrel after drug-eluting stent implantation

Background information of the condition:

Drug Eluting Stents (DES) Implantation DES were invented to reduce restenosis compared to bare metal stents (8% vs. 25%1,2 respectively). The process responsible for stent stenosis is delayed with drugs (sirolimus [rapamycin] and paclitaxel); however this benefit is offset by harm due to stent thrombosis (0.2-1.1%). Dual antiplatelet therapy is recommended to decrease the rate of stent thrombosis.

Syndiquer le contenu