25 Sep 2024 Evaluating prospective study registration and result reporting of trials conducted in Canada from 2009 to 2019
This live webinar has already taken place. Scroll down to view the video recording. To view the slide deck click on the ‘Download‘ button.
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In this TI Methods Speaker Series webinar, Dr. Mohsen Alayche, a first-year resident physician at McMaster University, talked about Canadian unpublished clinical trials from the past decade and discussed the findings of a published paper presented in Chicago at the Peer Review Congress and featured on CTV news.
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TITLE: Evaluating prospective study registration and result reporting of trials conducted in Canada from 2009 to 2019
WHEN: Wednesday, September 25th, 2024 at 12:00 noon PDT [convert to your local time]
WHERE: free online webinar.
SPEAKER: Dr. Mohsen Alayche, first-year resident physician, McMaster University.
About the topic: Adherence to study registration and reporting best practices is vital to fostering evidence-based medicine. Mohsen and his co-investigators identified all registered clinical trials on ClinicalTrials.gov conducted in Canada as of 2009 and completed by 2019. A cross-sectional analysis of those trials assessed prospective registration, subsequent result reporting in the registry, and subsequent publication of study findings. The lead sponsor, phase of study, clinical trial site location, total patient enrollment, number of arms, type of masking, type of allocation, year of completion, and patient demographics were examined as potential effect modifiers to these best practices. A total of 6720 trials were identified. From 2009 to 2019, 59% (n = 3,967) of them were registered prospectively, and 32% (n = 2138) had neither their results reported nor their findings published. Of the 3763 trials conducted exclusively in Canada, 3% (n = 123) met all three criteria of prospective registration, reporting in the registry, and publishing findings. Overall, the odds of having adherence to all three practices concurrently in Canadian trials decrease by 95% when compared with international trials. This study concluded that Canadian clinical trials substantially lack adherence to study registration and reporting best practices. Knowledge of this widespread non-compliance should motivate stakeholders in the Canadian clinical trial ecosystem to address and continue to monitor this problem. To view the slide deck click on the ‘Download‘ button.
About the speaker: Dr. Mohsen Alayche is a first-year resident physician at McMaster University. He completed medical school at the University of Ottawa, holds a BSc (Hons) in Biomedical Science with a minor in Music and completed a year of law school. His research at the Children’s Hospital of Eastern Ontario, Massachusetts General Hospital, and The Ottawa Hospital spans neuro-oncology, thoracic surgery, emergency medicine, hematology, and Journalology. His recent publication uncovered significant deficiencies in Canadian Open Science, capturing global media interest. He presented his findings from the podium at the Ninth International Congress on Peer Review and Scientific Publication in Chicago. As a physician, Mohsen recognizes the importance of evidence-based medicine that is published with scientific integrity.
About the TI Methods Speaker Series: The TI Methods Speaker Series are offered free of charge and everyone is welcome. The event is usually held at noon on the last Wednesday of each month via Zoom videoconference. The presentations are recorded and the video recordings are posted online. Click here to view the list of talks offered in 2024.
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