A systematic review of single-inhaler triple triple therapy for treatment of adult patients with moderate-to-severe chronic obstructive pulmonary disease (COPD)

17 Mar 2025 A systematic review of single-inhaler triple triple therapy for treatment of adult patients with moderate-to-severe chronic obstructive pulmonary disease (COPD)

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Please note that a revised version of this report was posted on May 8, 2025 and replaced the original version from March 2025. 

This is an update of a 2018 TI DAWG systematic review on the comparative effects of single-inhaler triple therapy versus corresponding dual therapy (LAMA/LABA or ICS/LABA) on moderate to severe exacerbations, total mortality, quality of life and dyspnea symptoms in COPD patients at “high risk” of exacerbation.