Introduction Letters #24, 27 and 42 recommended statin therapy for patients with ischemic heart disease (secondary prevention) based on 3 relevant randomized controlled trials (RCTs): 4S1, CARE2, and LIPID3. Letter #48 pooled the data from the...
Click here to go to a comment regarding Therapeutics Letter #48, posted on October 16, 2003 about the evidence of benefit for primary prevention in women. Two important questions regarding statin therapy are: What is the...
ALLHAT The results from the largest hypertension trial ever conducted, the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), have been published.1,2 Over 30,000 patients with mild to moderate hypertension plus at least one...
The Women's Health Initiative (WHI) trial is a striking example of how scientific evidence can improve prescribing practice.1 Therapeutics Letter 30 reviewed the evidence on hormone replacement therapy in 1999. Evidence then available showed that...