What is the impact of PRISMA-NMA in published NMAs? Which items require attention and improvement? What is the prevalence of inconsistency, and its association with different NMA characteristics? NMAs published after 2015 more frequently reported...
Vignette: An 83 year old faces conflict between her own preference for a simpler medication regime and a specialist who emphasizes that she will “need” to take her 8 drugs (14 doses/day) “for the rest of...
Tramadol was marketed as an opioid analgesic in Germany in 1977, but not licenced in Canada until 2005. Health Canada has announced that it will add tramadol to Schedule I of the Controlled Drugs and...
Therapeutics Letters 48, 49 and 77 summarized the effects of statins in secondary and primary prevention populations studied in randomized controlled trials (RCTs).1,2,3 This best available evidence comes from RCTs that enrolled mostly men aged...