Background Information of the Condition Pneumonia is the leading cause of death from infection, particularly among elderly and hospitalized patients. 1 Diagnosis is based on history, co-morbidities, physical findings, and chest x-ray. S. pneumoniae accounts for up to 50% of community-acquired pneumonia caused by bacteria.2 Drug (Product Monograph)3, 4 Category: Levofloxacin, the L-isomer of the … [Read more...]
The Drug Assessment Working Group (DAWG) is committed to analyze scientific evidence on the effectiveness and safety of drug therapies used in Canada. They systematically review and, when appropriate, critically appraise research relevant to new and existing drugs. Often the goal is to discover whether a new drug provides a therapeutic advantage over existing similar drug therapy for a clinical condition.
The Therapeutics Initiative has a dedicated team of researchers that is committed to the highest standards of research. In addition to reports on various new and existing drugs, the DAWG also contributes to the federal Common Drug Review (CDR), a national program set up to reduce duplication, and provide equal access to high level evidence and expert advice, thereby contributing to the quality and sustainability of Canadian public drug plans. The DAWG has contributed to many of the CDR reviews.
Below is a list of completed DAWG reports with links to the executive summaries.
Background Information of the Condition Chronic bronchitis is a subset of chronic obstructive pulmonary disease defined by a productive cough for at least 3 months in duration in each of 2 consecutive years, which may include an acute exacerbation of increased sputum production and purulence, and increased dyspnea. An increased respiratory rate and wheezing, lethargy and elevated temperature are … [Read more...]
Belorussian translation (courtesy of Nadejda Dobkina): http://onlinepharmacycheck.com/~doc/mesalamine-active-be Background information of the condition: Ulcerative Colitis (UC) is the chronic inflammation of colon and rectum.1 There is currently no known cure for ulcerative colitis, but it can be managed by medication. Based on four randomized controlled trials (RCTs) in 892 patients with … [Read more...]
Background Information of the Condition Acute bacterial sinusitis is a common, usually self-limited condition often associated with allergies and environmental irritants, as well as co-infection with viruses and fungi. Acute bacterial sinusitis is 200 times less common than viral rhinosinusitis. Symptoms and signs suggesting bacterial, as opposed to viral sinusitis include purulent nasal … [Read more...]
Background Information of the ConditionAcute bacterial sinusitis is a common, usually self-limited condition often associated with allergies and environmental irritants, as well as co-infection with viruses and fungi. Acute bacterial sinusitis is 200 times less common than viral rhinosinusitis. Symptoms and signs suggesting bacterial, as opposed to viral sinusitis include purulent nasal discharge … [Read more...]
Background information of the condition:Bipolar disorder Type I is characterized by at least one manic episode, with or without major depression. Patients are often symptomatically ill for nearly half of the time and their most frequent symptoms are depression, followed distantly by mania/hypomania, and then mixed episodes. 1 Drugs used for treatment of acute mania are: lithium, valproate … [Read more...]
Background Information of the ConditionGrowth hormone (GH) is synthesized and released from the anterior pituitary gland. GH releasing hormone stimulates GH secretion and somatostatin inhibits it. After peaking in puberty, endogenous GH secretion declines by about 14% per decade (Fisker, S et al 2005). Adults with GH deficiency include those with childhood-onset GH deficiency, those who have had … [Read more...]
Background information of the condition1Drug therapy reduces total cholesterol levels, but their benefit in terms of mortality and morbidity vary with different drug classes. Statins have been shown to provide a cardiovascular and total mortality benefit in four secondary prevention trials. Despite the lack of reporting of total serious adverse events in these 4 trials, one measure of overall … [Read more...]
Background information of the condition:Drug Eluting Stents (DES) Implantation DES were invented to reduce restenosis compared to bare metal stents (8% vs. 25%1,2 respectively). The process responsible for stent stenosis is delayed with drugs (sirolimus [rapamycin] and paclitaxel); however this benefit is offset by harm due to stent thrombosis (0.2-1.1%). Dual antiplatelet therapy is recommended … [Read more...]
Background Information of the ConditionWeight loss in AIDS patients results from loss of appetite (anorexia), wasting of muscle and adipose tissues (cachexia), and leads eventually in death. Adequate treatments are needed to prevent malnutrition. The goals of therapy in AIDS patients who are anorexic and cachexic are to increase appetite, increase or maintain weight, and increase … [Read more...]