Background information of the conditionPulmonary Arterial Hypertension (PAH) is a rare and potentially fatal disorder. It is manifested by dyspnea on exertion, syncope and signs and symptoms of right heart failure. In congenital heart disease (CHD) that involves left to right shunting, PAH generally develops due to increase in pulmonary blood flow causing microvascular change as the result … [Read more...]
The Drug Assessment Working Group (DAWG) is committed to analyze scientific evidence on the effectiveness and safety of drug therapies used in Canada. They systematically review and, when appropriate, critically appraise research relevant to new and existing drugs. Often the goal is to discover whether a new drug provides a therapeutic advantage over existing similar drug therapy for a clinical condition.
The Therapeutics Initiative has a dedicated team of researchers that is committed to the highest standards of research. In addition to reports on various new and existing drugs, the DAWG also contributes to the federal Common Drug Review (CDR), a national program set up to reduce duplication, and provide equal access to high level evidence and expert advice, thereby contributing to the quality and sustainability of Canadian public drug plans. The DAWG has contributed to many of the CDR reviews.
Below is a list of completed DAWG reports with links to the executive summaries.
Background information of the conditionType 2 Diabetes Mellitus: is a chronic disease in which the pancreas is not making, or the body is not appropriately using insulin. It is associated with increased risk of cardiovascular disease, limb amputation, retinopathy, nephropathy and neuropathy and premature death. If diet and exercise do not control symptoms from elevated blood sugar; drug … [Read more...]
Background information of the condition:Multiple sclerosis: is a degenerative white-matter disease and may present with acute symptoms of neurological impairment (known herein as clinically isolated syndrome - CIS). CIS is the clinical stage of relevance to this systematic review. Based on several cohort studies, the estimated risk to develop multiple sclerosis (MS) after CIS is about 45% … [Read more...]
Background information of the conditionVenous thromboembolism (VTE) in patients with cancer: Cancer is a major risk factor for VTE with the 12-month cumulative incidence of recurrent VTE three times higher than patients without cancer [20.7% vs. 6.8%, respectively] (1). Oral anticoagulants (OAC) - warfarin and acenocoumarol, are the standard long-term (3-6 month) therapy for secondary … [Read more...]
Background information of the conditionDiabetes Mellitus: is a chronic disease in which the body does not produce or properly use insulin. Type 1 diabetes is an autoimmune disease in which the patient has to take insulin daily to live because the pancreas make little or no insulin. In type 2 diabetic patients, the pancreas is not making enough insulin, or the body cannot use the insulin … [Read more...]
Background information on the conditionDiabetes Mellitus is a chronic disease in which the body does not produce or properly use insulin. Type 1 diabetes is an autoimmune disease in which the patient has to take insulin daily to live because the pancreas make little or no insulin. In type 2 diabetic patients, the pancreas is not making enough insulin, or the body cannot use the insulin effectively … [Read more...]