Twenty-Five Pearls from 25 years (part one) Twenty-Five Pearls from 25 years (part two) … [Read more...]
The Value of Independent Drug Assessment
THE VALUE OF INDEPENDENT DRUG ASSESSMENT Issue: BCMJ, vol. 61 , No. 3 , April 2019 , Pages 125-127 Premise By: James M. Wright, MD, PhD, FRCPC Ken Bassett, MD, PhD Thomas L. Perry Jr., MD Aaron M. Tejani, PharmD Type 2 diabetes in British Columbia as a case study to explain the work of UBC’s Therapeutics Initiative. Read more... … [Read more...]
Using antipsychotic drugs for depression not best treatment
KHN launches Pre$cription for Power
Pre$cription for Power: Patient Advocacy Groups Take In Millions From Drugmakers. Is There A Payback? Kaiser Health News (KHN) has launched “Pre$cription for Power,” a groundbreaking database to expose Big Pharma’s ties to patient groups. Pharmaceutical companies gave at least $116 million to patient advocacy groups in a single year (2015 — the most recent full year in which documents required by … [Read more...]
What We Mean When We Say Evidence-Based Medicine
People understand different things by this term, and the arguments don’t divide along predictable partisan lines, either. By Aaron E. Carroll Dec. 27, 2017 … [Read more...]
The List: Yes, there are industry-independent health care experts
If anyone ever says that he or she can’t find an industry-independent expert for a news story or for an FDA committee, they just haven’t looked hard enough. For 9 years, HealthNewsReview.org have hosted what is, to the best of our knowledge, a one-of-a-kind list of health care industry-independent experts. Now that list has been revised, with new names, removing even more excuses for those … [Read more...]
Number needed to treat (NNT) in clinical literature: an appraisal
The number needed to treat (NNT) is an absolute effect measure that has been used to assess beneficial and harmful effects of medical interventions. Several methods can be used to calculate NNTs, and they should be applied depending on the different study characteristics, such as the design and type of variable used to measure outcomes. Whether or not the most recommended methods have been applied … [Read more...]
Should Patients Continue to Receive Statins Once They Reach 80 Years of Age?
Rethinking the Appraisal and Approval of Drugs for Fracture Prevention
After decades of widespread use, effectiveness of drugs for osteoporosis remains uncertain, yet adverse effects are more apparent. Well-designed and large trials over prolonged follow-up periods, measuring clinically relevant outcomes as hip and other disabling fractures, are urgently needed in order to properly understand the harm-benefit ratio of commonly prescribed drugs. Regulatory agencies … [Read more...]
Misfire: The 2012 Ministry of Health Employment Terminations and Related Matters
April 6, 2017, Victoria, BC: B.C. Ombudsperson Jay Chalke released his investigation report today, titled Misfire: The 2012 Ministry of Health Employment Terminations and Related Matters. The Ombudsperson investigation began in September 2015. Almost 4.7 million records were obtained, and 130 witnesses provided evidence under oath during 540 hours of interviews. The Ombudsperson investigation … [Read more...]
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