This is the first Prescribing Portrait produced by the Therapeutics Initiative, in 2020. To view this Portrait in PDF format click on the DOWNLOAD button. Best Evidence for Prescribing PPIs for GERD/Heartburn Do they work? Yes, PPIs can be effective for heartburn symptoms. Specifically: PPIs can improve non-erosive heartburn more than H2RAs (e.g. cimetidine) RR 0.78 and more than … [Read more...]