[130] Evidence for statins in people over 70
Therapeutics Letters 48, 49 and 77 summarized the effects of statins in secondary and primary prevention populations studied in randomized controlled trials (RCTs).1,2,3 This best available evidence comes from RCTs that enrolled mostly men aged 50-70. There is much less evidence for use of statins after age 70. Yet in 2020 47% of men and 33% of women over 70 in British Columbia took a statin. … [Read more...]
[129] Mirtazapine: Update on efficacy, safety, dose response
Soon after mirtazapine was licensed in Canada, a 2002 Therapeutics Letter concluded that it has “no proven efficacy or safety advantage over other antidepressant therapies”.1 Mirtazapine was approved for symptomatic relief of depressive illness and marketed as an alternative to selective serotonin reuptake inhibitors (SSRIs) which had dominated the antidepressant market from the late 1980s.2 As … [Read more...]
[Jun 16] Restoring Invisible and Abandoned Trials – Preliminary results of the restoration of the FOURIER (evolocumab) trial
PRESENTER: Dr. Erviti is a qualified hospital pharmacist. In 1992, he worked as an assistant professor of Pharmacology in the Public University of Navarre and earned his doctorate in 1994. From 1994 to 2003, Juan joined the National Health Service where he worked as a clinical pharmacist. In 2003 he was appointed as the Head of the Drug Information Unit in the National Health Service in Navarre, … [Read more...]
Off-label postpartum use of domperidone in Canada: a multidatabase cohort study
Carolina Moriello, MSc, J. Michael Paterson, MSc, Pauline Reynier, MSc, Matthew Dahl, BSc, Wusiman Aibibula, MD PhD, Anat Fisher, MD PhD, John-Michael Gamble, BSc(Pharm) PhD, I fan Kuo, PharmD MSc, Paul E. Ronksley, PhD, Brandace Winquist, PhD, Kristian B. Filion, PhD for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators. Off-label postpartum use of domperidone in … [Read more...]
Comparison of Pregnancy Outcomes of Patients Treated With Ondansetron vs Alternative Antiemetic Medications in a Multinational, Population-Based Cohort
Colin R. Dormuth, Brandace Winquist, Anat Fisher, et al JAMA Netw Open. 2021;4(4):e215329. doi:10.1001/jamanetworkopen.2021.5329 Key Points Question: What is the association between ondansetron exposure during pregnancy and the risk of adverse fetal outcomes? Findings: In this meta-analysis of cohort studies of 456 963 pregnancies in 3 countries, treatment with ondansetron was not … [Read more...]
[128] Drug Safety Advisories: A need for international coordination
Vanessa Young of Oakville, Ontario died suddenly on March 19, 2000 at age 15. She was taking cisapride, a drug prescribed to “enhance stomach emptying” of whose link to fatal cardiac dysrhythmias the US FDA warned American doctors two months earlier.Health Canada delayed its own alert until after Vanessa’s sudden cardiac arrest at home.1 Her father Terence Young became the Conservative MP for … [Read more...]
[127] Audit and Feedback: Personal Prescribing Portrait
Primary care prescribers who treat a wide variety of conditions in community-dwelling patients require broad prescribing knowledge.1,2 The number of existing drug options and new drugs available each year has created a challenging work environment. There is a corresponding need to find innovative methods to help community-based physicians monitor and evaluate the appropriateness of their … [Read more...]
[May 26] TI Methods Speaker Series: What’s counted and what counts: Metrics in scholarly publishing
TI Methods Speaker Series The TI Methods Speaker Series are offered free of charge and everyone is welcome. The event is held at noon on the last Wednesday of each month and used to take place in Rudy North Lecture Theatre (CBH 101) in the Centre for Brain Health, UBC Point Grey Campus. During the COVID-19 pandemic, while physical distancing measures are in effect, the TI Methods Speaker Series … [Read more...]
[May 12] TI Best Evidence Webinar: ActionADE: Assessing the Impact of Information Continuity on Health Outcomes
PRESENTER: Dr. Corinne Hohl is an associate Professor in UBC’s Department of Emergency Medicine, scientist at the Centre for Clinical Epidemiology and Evaluation, and an associate member of UBC’s School of Population and Public Health. She practices emergency medicine at Vancouver General Hospital. Dr. Hohl’s main interests are in patient safety, health systems innovations and drug safety and … [Read more...]
Legacy prescriptions for cardiovascular risk reduction (ASA, BB, ACEI, statins): what we know (and don’t know) about lifelong therapy
Dr. John Mandrola, MD, FACC gave this presentation on October 17th, 2020 at the "Bringing Best Evidence to Clinicians" virtual conference. Dr. Mandrola practices cardiac electrophysiology in Louisville KY. He writes and podcasts for the online medical news site, Medscape. In the last few years, he has participated in numerous academic collaborations. In 2019, he co-authored 19 peer-reviewed … [Read more...]
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