[128] Drug Safety Advisories: A need for international coordination
Vanessa Young of Oakville, Ontario died suddenly on March 19, 2000 at age 15. She was taking cisapride, a drug prescribed to “enhance stomach emptying” of whose link to fatal cardiac dysrhythmias the US FDA warned American doctors two months earlier.Health Canada delayed its own alert until after Vanessa’s sudden cardiac arrest at home.1 Her father Terence Young became the Conservative MP for … [Read more...]
[127] Audit and Feedback: Personal Prescribing Portrait
Primary care prescribers who treat a wide variety of conditions in community-dwelling patients require broad prescribing knowledge.1,2 The number of existing drug options and new drugs available each year has created a challenging work environment. There is a corresponding need to find innovative methods to help community-based physicians monitor and evaluate the appropriateness of their … [Read more...]
[126] Serious harms with long-term PPI use in older adults
Proton pump inhibitors (PPIs) were introduced in 1988. Health Canada, professional, and academic groups all agree that they should be prescribed at the lowest dose and for the shortest duration appropriate to the condition treated. However, PPI use continues to expand. Between 2000 and 2018 BC’s population grew by 20%, but use of PPIs increased by 257%. In 2018, 442,559 British Columbians (9% of … [Read more...]
Effectiveness and Safety among Direct Oral Anticoagulants in Non Valvular Atrial Fibrillation: A Multi‐Database Cohort Study with Meta‐Analysis
British Journal of Clinical Pharmacology, November 2020 Madeleine Durand, Mireille E. Schnitzer, Menglan Pang, Greg Carney, Sherif Eltonsy, Kristian B. Filion, Anat Fisher, Min Jun, I. fan Kuo, Alexis Matteau, J. Michael Paterson, Jacqueline Quail, Christel Renoux for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators Abstract Background: There are conflicting … [Read more...]
[Nov 25] TI Methods Speaker Series: Communicating the results of a systematic review in simple statements
TI Methods Speaker Series The TI Methods Speaker Series are offered free of charge and everyone is welcome. The event is held at noon on the last Wednesday of each month and used to take place in Rudy North Lecture Theatre (CBH 101) in the Centre for Brain Health, UBC Point Grey Campus. During the COVID-19 pandemic, while physical distancing measures are in effect, the TI Methods Speaker Series … [Read more...]
[Nov 18] Doctors and the Pharmaceutical Industry: Too close for comfort?
TI Best Evidence Webinar ABOUT THE TOPIC: The Canadian medical profession and the pharmaceutical history have a long history of a close relationship. This talk will explore what the relationship looks like now and what the implications are for the way that doctors’ practice. PRESENTER: Joel Lexchin graduated from the University of Toronto medical school in 1977 and for the past 32 years … [Read more...]
[Oct 28] TI Methods Speaker Series: Innovations in Methods and Evaluation of Guideline Development
TI Methods Speaker Series The TI Methods Speaker Series are offered free of charge and everyone is welcome. The event is held at noon on the last Wednesday of each month and used to take place in Rudy North Lecture Theatre (CBH 101) in the Centre for Brain Health, UBC Point Grey Campus. During the COVID-19 pandemic, while physical distancing measures are in effect, the TI Methods Speaker Series … [Read more...]
Tofacitinib Persistence in Patients with Rheumatoid Arthritis: A Retrospective Cohort Study
The Journal of Rheumatology, October 2020 Anat Fisher, Marie Hudson, Robert W. Platt and Colin R. Dormuth for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators Abstract Objective: To compare medication persistence of tofacitinib with persistence of injectable biological disease-modifying antirheumatic drugs (bDMARD) in patients with rheumatoid … [Read more...]
Sodium–Glucose Cotransporter 2 Inhibitors and the Risk of Below-Knee Amputation: A Multicenter Observational Study
Diabetes Care Aug 2020, dc200267; DOI: 10.2337/dc20-0267 Oriana Hoi Yun Yu, Sophie Dell’Aniello, Baiju R. Shah, Vanessa C. Brunetti, Jean-Marc Daigle, MichaelFralick, Antonios Douros, Nianping Hu, Silvia Alessi-Severini, Anat Fisher, Shawn C. Bugden, Paul E.Ronksley, Kristian B. Filion, Pierre Ernst, Lisa M. Lix for the Canadian Network for Observational Drug Effect Studies (CNODES) … [Read more...]
[Sep 30] TI Methods Speaker Series: A Practical Introduction to Propensity Score Analysis using R
TI Methods Speaker Series The TI Methods Speaker Series are offered free of charge and everyone is welcome. The event is held at noon on the last Wednesday of each month and used to take place in Rudy North Lecture Theatre (CBH 101) in the Centre for Brain Health, UBC Point Grey Campus. During the COVID-19 pandemic, while physical distancing measures are in effect, the TI Methods Speaker Series … [Read more...]
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