The first three Therapeutics Letters focused on complaints related to the upper gastrointestinal tract, a common presentation to the primary care physician.1-3 These Letters reviewed evidence about H2-blockers, eradication of Helicobacter pylori, and drugs used for gastroesophageal reflux. However, they also raised concerns about chronic acid suppression by daily dosing of omeprazole, the first … [Read more...]
[99] Comparative effectiveness of proton pump inhibitors
Six previous Therapeutics Letters reported information about the benefits and harms of different proton pump inhibitors (PPIs).1-6 These drugs work by irreversibly inhibiting gastric H+K+ ATPase (the proton pump) in the stomach. They inhibit both basal and stimulated acid secretion and are used in a number of clinical settings: gastroesophageal reflux disease (GERD), reflux esophagitis, peptic … [Read more...]
