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Home > Therapeutics Letter

Therapeutics Letter

This is a bimonthly publication targeting identified problematic therapeutic issues in a brief, simple and practical manner. The process leading up to publication involves a rigorous, systematic literature review by different working groups of the Therapeutics Initiative, the creation of a draft which is circulated for comment among a sizeable group of over 100 local, national and international specialists with expertise in the particular therapeutic area and the commission of original artwork/illustration. The message is developed collaboratively by different working groups of the Therapeutics Initiative. The current Editor in Chief is Dr. Tom Perry, Chair of the Education Working Group of the Therapeutics Initiative.

Therapeutics Letters on common therapies have been regularly published since 1994 and distributed free of charge to physicians and pharmacists in British Columbia to increase awareness and improve prescription habits.

The Therapeutics Letter is a member of the International Society of Drug Bulletins (ISDB), a world-wide network of independent drug bulletins that aims to promote international exchange of quality information on drugs and therapeutics.

ISSN: 2369-8691 (Online)
ISSN: 2369-8683 (Print)

[128] Drug Safety Advisories: A need for international coordination

December 3, 2020 Therapeutics Letter Leave a Comment

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Vanessa Young of Oakville, Ontario died suddenly on March 19, 2000 at age 15. She was taking cisapride, a drug prescribed to “enhance stomach emptying” of whose link to fatal cardiac dysrhythmias the US FDA warned American doctors two months earlier.Health Canada delayed its own alert until after Vanessa’s sudden cardiac arrest at home.1 Her father Terence Young became the Conservative MP for … [Read more...]

[127] Audit and Feedback: Personal Prescribing Portrait

August 27, 2020 Therapeutics Letter Leave a Comment

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Primary care prescribers who treat a wide variety of conditions in community-dwelling patients require broad prescribing knowledge.1,2 The number of existing drug options and new drugs available each year has created a challenging work environment. There is a corresponding need to find innovative methods to help community-based physicians monitor and evaluate the appropriateness of their … [Read more...]

[126] Serious harms with long-term PPI use in older adults

June 26, 2020 Therapeutics Letter Leave a Comment

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Proton pump inhibitors (PPIs) were introduced in 1988. Health Canada, professional, and academic groups all agree that they should be prescribed at the lowest dose and for the shortest duration appropriate to the condition treated. However, PPI use continues to expand. Between 2000 and 2018 BC’s population grew by 20%, but use of PPIs increased by 257%. In 2018, 442,559 British Columbians (9% of … [Read more...]

[125] Can prescribers avoid contributing to opioid use disorder?

June 4, 2020 Therapeutics Letter Leave a Comment

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Case vignette: A 21 y/o has surgery for a condition expected to improve. He fills a discharge prescription for 5 days of an opioid at a standard dose. At 1-week follow-up with his family doctor for suture removal, he describes ongoing pain. Is a renewal of opioid appropriate, potentially dangerous, or both? Aggressive promotion of opioids for chronic non-cancer pain (CNCP) began in the … [Read more...]

[Special Edition: March 2020] Pill splitting: Making the most of meds in a time of need

March 23, 2020 Therapeutics Letter 16 Comments

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Français | Español | Português | 繁體中文 | 简体中文| عربي Clinical vignette A 54 year-old mechanic with type 2 diabetes and hypertension had a myocardial infarction in 2015. He currently takes ASA 81mg/d (over the counter) plus 6 generic prescription drugs dispensed monthly: atorvastatin 40mg/d ramipril 5mg/d empagliflozin 25mg/d escitalopram 10mg/d sildenafil 50mg 4 … [Read more...]

[Edição Especial Março 2020] Fracionamento de comprimidos: aproveitando ao máximo as medicações em tempos de necessidade

April 1, 2020 Therapeutics Letter Leave a Comment

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English | Français | Español | 繁體中文 | 简体中文 | عربي Vinheta clínica Um mecânico de 54 anos com diabetes tipo 2 e hipertensão teve um infarto do miocárdio em 2015. Ele toma atualmente 81 mg de aspirina (venda sem receita) mais 6 drogas genéricas dispensadas mensalmente: atorvastatina 40mg/d ramipril 5mg/d empagliflozina 25mg/dia escitalopram 10mg/d sildenafil 50mg 4 … [Read more...]

药片分割:在有需要的时候充分利用药物

April 7, 2020 Therapeutics Letter Leave a Comment

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繁體中文 | English | Français | Español | Português | عربي 模拟案例 一名患有二型糖尿病的54岁技工在2015年心脏病发作。 现在,他服用的药物包括: 阿托伐他汀(Atorvastatin) 40毫克/天 雷米普利 (Ramipril) 5毫克/天 阿司匹林 (Aspirin) 81毫克/天 (非处方药) 恩帕列净 (Empagliflozin) 25毫克/天 依他普仑 (Escitalopram) 10毫克/天 西地那非 (通用品牌伟哥) (Sildenafil)每月四次50毫克 度洛西汀(Duloxetine) 90毫克/天 他能全职工作并且身体状况一直稳定,但由於他刚被解雇,女儿的餐馆又结业了,因此他担心可能无法支付药物治疗的费用。 … [Read more...]

藥片分割:在有需要的時候充分利用藥物

April 7, 2020 Therapeutics Letter Leave a Comment

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简体中文 | English | Français | Español | Português | عربي 模擬案例 一名患有二型糖尿病的54歲技工在2015年心臟病發作。 現在,他服用的藥物包括: 阿托伐他汀(Atorvastatin) 40毫克/天 雷米普利 (Ramipril) 5毫克/天 阿司匹林 (Aspirin) 81毫克/天 (非處方藥) 恩帕列淨 (Empagliflozin) 25毫克/天 依他普侖 (Escitalopram) 10毫克/天 西地那非 (通用品牌偉哥) (Sildenafil)每月四次50毫克 度洛西汀(Duloxetine) 90毫克/天 他能全職工作並且身體狀況一直穩定,但由於他剛被解雇,女兒的餐館又結業了,因此他擔心可能無法支付藥物治療的費用。 … [Read more...]

مقالة علمية شهر آذار 2020] تقسيم حبة الدواء يحقق الاستفادة القصوى من الأدوية في الظروف الصعبة]

April 13, 2020 Therapeutics Letter Leave a Comment

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English | Français | Español | Português | 繁體中文 | 简体中文 حالة سريرية ميكانيكي يبلغ من العمر 54 عامًا يعاني من مرض السكري من النوع 2 وارتفاع ضغط الدم وقد أصيب باحتشاء العضلة القلبية في عام 2015. يأخذ حاليا ASA 81mg / d الأسبرين من دون وصفة طبيب، بالإضافة إلى 6 أدوية يتم صرفها له شهريًا بناءً على وصفة الطبيب: Atorvastatin 40mg/d Ramipril 5mg/d Empagliflozin 25mg/d Escitalopram … [Read more...]

[124] Your views of the Therapeutics Initiative: 2019 Survey

February 16, 2020 Therapeutics Letter 5 Comments

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In 2019, the Therapeutics Initiative completed its fifth readership survey to evaluate perceptions of our academic unit and the impact of TI events. We conducted similar surveys in 1996, 2000, 2006, and 2011. In 2019 we invited a 10% random sample of all registered pharmacists in British Columbia (N=588) and a 10% random sample of physicians who receive our letter by mail (N=643) to participate in … [Read more...]

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