Isotretinoin, a teratogen, is widely used to treat cystic acne. Although the risks of pregnancy during isotretinoin therapy are well recognized, there are doubts about the level of adherence with the pregnancy prevention program in Canada. We evaluated the effectiveness of the Canadian pregnancy prevention program for female users of isotretinoin (aged 12-48 yr) for the period 1996 to 2011 in 4 … [Read more...]
PharmacoEpidemiology Group (PEG) conducts research in the areas prescription drug utilization, epidemiological research methods, evaluation of drug policy and educational interventions, and drug safety and effectiveness. Selected journal articles and reports co-authored by PEG members are listed below.
Incretin based drugs and the risk of pancreatic cancer
In this large population study co-authored by Therapeutics Initiative researcher Dr. Colin Dormuth, "the use of incretin based drugs was not associated with an increased risk of pancreatic cancer compared with sulfonylureas. Although this potential adverse drug reaction will need to be monitored long term owing to the latency of the cancer, these findings provide some reassurance on the safety of … [Read more...]
Higher potency statins and the risk of new diabetes: multicentre, observational study of administrative databases
Higher potency statins and the risk of new diabetes: multicentre, observational study of administrative databases Colin R Dormuth, Kristian B Filion, J Michael Paterson, Matthew T James, Gary F Teare, Colette B Raymond, Elham Rahme, Hala Tamim, Lorraine Lipscombe, for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators BMJ 2014; 348 doi: … [Read more...]
BMJ: Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analys
Authors Colin R Dormuth, assistant professor, Brenda R Hemmelgarn, associate professor, J Michael Paterson, scientist, Matthew T James, assistant professor, Gary F Teare, director of quality management and analysis, Colette B Raymond, research scientist, Jean-Philippe Lafrance, assistant professor, Adrian Levy, head, Amit X Garg, professor of medicine, Pierre Ernst, professor of … [Read more...]
Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Dormuth CR, Hemmelgarn BR, Paterson JM, James MT, Teare GF, Raymond CB, et al … [Read more...]
Effectiveness of tiotropium and ipratropium in prevention of hospital readmission for COPD: A population-based cohort study
Kawasumi Y, Paterson M, Morrow RL, Miller TA, Bassett K, Wright JM, and Dormuth CR … [Read more...]
Is thiazolidinedione use a factor in delaying the need for insulin therapy in type-2 diabetics? A population-based cohort stud
Carney GA, Bassett K, Wright JM, Dormuth CR … [Read more...]
Effect of a centralized prescription network on inappropriate prescriptions for opioid analgesics and benzodiazepines
Dormuth CR, Miller TA, Huang A, Mamdani MM, Juurlink DN … [Read more...]
Isotretinoin use and the risk of inflammatory bowel disease: A populuation-based cohort study
Alhusayen RO, Juurlink DN, Mamdani MM, Morrow RL, Shear NH, Dormuth CR … [Read more...]
Using policy simulation to predict drug plan expenditure when planning reimbursement changes.
Dormuth CR, Burnett S, Schneeweiss S … [Read more...]
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