Daneman N, Chateau D, Dahl M, Zhang J, Fisher A, Sketris IS, Quail J, Marra F, Ernst P, Bugden S, for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators Clinical Microbiology and Infection. 2019 https://doi.org/10.1016/j.cmi.2019.10.016 Abstract Objectives: The United States Food & Drug Administration released an advisory in 2016 that fluoroquinolones be … [Read more...]
PharmacoEpidemiology Group (PEG) conducts research in the areas prescription drug utilization, epidemiological research methods, evaluation of drug policy and educational interventions, and drug safety and effectiveness. Selected journal articles and reports co-authored by PEG members are listed below.
Comparative Effectiveness Of Fluoroquinolone Antibiotic Use In Uncomplicated Acute Exacerbations Of COPD: A Multi-Cohort Study
Ernst P, Dahl M, Chateau D, Daneman N, Quail J, Sketris IS, Fisher A,Zhang J, Bugden S, on behalf of the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators International Journal of Chronic Obstructive Pulmonary Disease. 2019:14 2939–2946. https://doi.org/10.2147/COPD.S226324 Abstract Purpose: Fluoroquinolone antibiotics are associated with rare, but severe … [Read more...]
Comparison of cholinesterase inhibitor safety in real-world practice
Carney G, Bassett K, Wright JM, Maclure M, McGuire N, Dormuth CR Alzheimer's & Dementia: Translational Research & Clinical Interventions. Volume 5, 2019, Pages 732-739. https://doi.org/10.1016/j.trci.2019.09.011 Highlights Galantamine was associated with fewer adverse events than donepezil or rivastigmine. Galantamine users experienced longer independent living. The … [Read more...]
Identifying sequential episodes of pharmacotherapy as a method for assessing treatment failure in comparative effectiveness research
Carney, G, Maclure, M, Bassett, K, Taylor, S, Dormuth, CR Pharmacoepidemiol Drug Saf. 2019; 1– 9. https://doi.org/10.1002/pds.4926 Abstract Purpose To describe and implement a novel method of measuring comparative effectiveness using sequential episodes of pharmacotherapy as a proxy for treatment failure. Methods Retrospective cohort study using linked deidentified data from the British … [Read more...]
Policy-induced selection bias in pharmacoepidemiology: The example of coverage for Alzheimer’s medications in British Columbia
Fisher A, Carney G, Bassett K, Maclure KM, Dormuth CR … [Read more...]
Influence of opioid prescribing standards on drug use among patients with long-term opioid use: a longitudinal cohort study
Morrow RL, Bassett K, Wright JM, Carney G, Dormuth CR … [Read more...]
Outcomes associated with hospital admissions for accidental opioid overdose in British Columbia: a retrospective cohort study
Morrow RL, Bassett K, Maclure M, Dormuth CR … [Read more...]
Tramadol and the risk of seizure: nested case-control study of US patients with employer-sponsored health benefits
Morrow RL, Dormuth CR, Paterson M, Mamdani MM, Gomes T, Juurlink DN; Canadian Drug Safety Effectiveness Research Network (CDSERN) … [Read more...]
Occurrence of pregnancy and pregnancy outcomes during isotretinoin therapy
Isotretinoin, a teratogen, is widely used to treat cystic acne. Although the risks of pregnancy during isotretinoin therapy are well recognized, there are doubts about the level of adherence with the pregnancy prevention program in Canada. We evaluated the effectiveness of the Canadian pregnancy prevention program for female users of isotretinoin (aged 12-48 yr) for the period 1996 to 2011 in 4 … [Read more...]
Incretin based drugs and the risk of pancreatic cancer
In this large population study co-authored by Therapeutics Initiative researcher Dr. Colin Dormuth, "the use of incretin based drugs was not associated with an increased risk of pancreatic cancer compared with sulfonylureas. Although this potential adverse drug reaction will need to be monitored long term owing to the latency of the cancer, these findings provide some reassurance on the safety of … [Read more...]
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