We are highlighting 2 recent articles published by members of the PharmacoEpidemiology Group (PEG) of the Therapeutics Initiative: Comparative effectiveness and safety of oral anticoagulants for atrial fibrillation in real-world practice: a population-based cohort study protocol US Food and Drug Administration Safety Advisories and Reporting to the Adverse Event Reporting System … [Read more...]
PharmacoEpidemiology Group (PEG) conducts research in the areas prescription drug utilization, epidemiological research methods, evaluation of drug policy and educational interventions, and drug safety and effectiveness. Selected journal articles and reports co-authored by PEG members are listed below.
New Publications from the TI PharmacoEpidemiology Group
We are highlighting 2 recent articles published by members of the PharmacoEpidemiology Group (PEG) of the Therapeutics Initiative: A rapid monitoring plan following a shift in coverage from brand name to biosimilar drugs for rheumatoid arthritis in British Columbia Cardiovascular and neuropsychiatric safety of smoking cessation pharmacotherapies in non‐depressed adults: a retrospective … [Read more...]
A rapid monitoring plan following a shift in coverage from brand name to biosimilar drugs for rheumatoid arthritis in British Columbia
Dormuth CR, Fisher A, Carney G Pharmacoepidemiology & Drug Safety. 2020 https://doi.org/10.1002/pds.4957 Abstract Purpose: To describe a rapid monitoring plan to assess the impacts of a shift in drug coverage for biosimilar drugs in British Columbia following the introduction of a new policy on 27 May 2019. The Biosimilars Initiative requires users of originator infliximab or … [Read more...]
Cardiovascular and neuropsychiatric safety of smoking cessation pharmacotherapies in non‐depressed adults: a retrospective cohort study
Carney G, Bassett K, Maclure M, Taylor S, Dormuth CR Addiction. 2020 https://doi.org/10.1111/add.14951 Abstract Background and aims: Pharmacotherapies for smoking cessation are widely prescribed, despite substantial concerns being raised regarding the potential increased risk of cardiovascular (CV) and neuropsychiatric adverse events associated with these treatments. This study aimed to … [Read more...]
Fluoroquinolone use for uncomplicated urinary tract infections in women: a retrospective cohort study
Daneman N, Chateau D, Dahl M, Zhang J, Fisher A, Sketris IS, Quail J, Marra F, Ernst P, Bugden S, for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators Clinical Microbiology and Infection. 2019 https://doi.org/10.1016/j.cmi.2019.10.016 Abstract Objectives: The United States Food & Drug Administration released an advisory in 2016 that fluoroquinolones be … [Read more...]
Comparative Effectiveness Of Fluoroquinolone Antibiotic Use In Uncomplicated Acute Exacerbations Of COPD: A Multi-Cohort Study
Ernst P, Dahl M, Chateau D, Daneman N, Quail J, Sketris IS, Fisher A,Zhang J, Bugden S, on behalf of the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators International Journal of Chronic Obstructive Pulmonary Disease. 2019:14 2939–2946. https://doi.org/10.2147/COPD.S226324 Abstract Purpose: Fluoroquinolone antibiotics are associated with rare, but severe … [Read more...]
Comparison of cholinesterase inhibitor safety in real-world practice
Carney G, Bassett K, Wright JM, Maclure M, McGuire N, Dormuth CR Alzheimer's & Dementia: Translational Research & Clinical Interventions. Volume 5, 2019, Pages 732-739. https://doi.org/10.1016/j.trci.2019.09.011 Highlights Galantamine was associated with fewer adverse events than donepezil or rivastigmine. Galantamine users experienced longer independent living. The … [Read more...]
Identifying sequential episodes of pharmacotherapy as a method for assessing treatment failure in comparative effectiveness research
Carney, G, Maclure, M, Bassett, K, Taylor, S, Dormuth, CR Pharmacoepidemiol Drug Saf. 2019; 1– 9. https://doi.org/10.1002/pds.4926 Abstract Purpose To describe and implement a novel method of measuring comparative effectiveness using sequential episodes of pharmacotherapy as a proxy for treatment failure. Methods Retrospective cohort study using linked deidentified data from the British … [Read more...]
Policy-induced selection bias in pharmacoepidemiology: The example of coverage for Alzheimer’s medications in British Columbia
Fisher A, Carney G, Bassett K, Maclure KM, Dormuth CR … [Read more...]
Influence of opioid prescribing standards on drug use among patients with long-term opioid use: a longitudinal cohort study
Morrow RL, Bassett K, Wright JM, Carney G, Dormuth CR … [Read more...]
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