Therapeutics Letter

This is a bi-monthly letter targeting identified problematic therapeutic issues (brief, simple, practical messages). The process involves a literature review and development of the message by different working groups of the Therapeutics Initiative. A draft of the letter is reviewed by specialists who are expert in the particular therapeutic area and members of the Scientific Information and Education Committee before the letter is disseminated. The Therapeutics Initiative is a member of the International Society of Drug Bulletins.
Issuesort icon Title
Issue 88 / Jul - Aug 2013 Filling the Evidence Gap: Pragmatic Randomized Controlled Trials in British Columbia Download View
Issue 87 / Jul - Aug 2012 High dose versus standard dose statins in stable coronary heart disease Download View
Issue 86 / Apr - Jun 2012 Your opinions of the Therapeutics Initiative: The 2011 Survey Download View
Issue 85 / Jan - Mar 2012 Clinical Pearls from Prescrire Download View
Issue 84 / Nov - Dec 2011 A Systematic Review of the Harms of Bisphosphonates Download View
Issue 83 / Sep - Oct 2011 A Systematic Review of the Efficacy of Bisphosphonates Download View
Issue 82 / Jul - Aug 2011 Clinical Hypertension Pearls from The Cochrane Library Download View
Issue 81 / Apr - Jun 2011 Self-Monitoring of Blood Glucose in Type 2 Diabetes Download View
Issue 80 / Jan - Mar 2011 Dabigatran for atrial fibrillation: Why we can not rely on RE-LY Download View
Issue 79 / Sep - Dec 2010 Is use of quetiapine for sleep evidence-based? Download View
Issue 78 / May - Aug 2010 Bisphosphonates: Do they prevent or cause bone fractures? Download View
Issue 77 / Mar - Apr 2010 Do statins have a role in primary prevention? An update. Download View
Issue 76 / Jan - Feb 2010 Are antidepressants safe in pregnancy? A focus on SSRIs Download View
Issue 75 / Jul - Dec 2009 Gabapentin for pain: New evidence from hidden data Download View
Issue 74 / Apr - Jun 2009 Increasing use of newer antipsychotics in children: A cause for concern? Download View
Issue 73 / Jan - Mar 2009 Atomoxetine for ADHD in Children and Adolescents Download View
Issue 72 / Nov - Dec 2008 Prescription drug costs: BC versus Canada Download View
Issue 71 / Sep - Oct 2008 Treatment of elevated blood pressure in the very elderly: Less is better Download View
Issue 70 / Jun - Aug 2008 Clinical Pearls from the most popular Cochrane reviews in 2007 Download View
Issue 69 / Mar - May 2008 What is the evidence for using CNS stimulants to treat ADHD in children? Download View
Issue 68 / Jan - Feb 2008 Glycemic Targets in Type 2 Diabetes Download View
Issue 67 / Nov - Dec 2007 Evaluating the Media as a source of Drug Therapy Information Download View
Issue 66 / Sep - Oct 2007 Is newer better? New drugs for treatment of overactive bladder Download View
Issue 65 / Jul - Aug 2007 Clinical implications of recent key therapeutic trials Download View
Issue 64 / May - Jun 2007 Your opinions of the Therapeutics Letter: The 2006 Survey Download View
Issue 63 / Mar - Apr 2007 Using Framingham for primary prevention cardiovascular risk assessment Download View
Issue 62 / Jan - Feb 2007 Mild Hypertension - An approach to using evidence in the decision making process Download View
Issue 61 / Oct - Dec 2006 What is the Common Drug Review? Download View
Issue 60 / Oct - Dec 2006 Clinical Pearls from Prescrire Download View
Issue 59 / Apr - Jul 2006 Increasing Drug Costs: Are we getting good value? Download View
Issue 58 / Jan - Mar 2006 Benign Prostatic Hypertrophy – An update on drug therapy Download View
Issue 57 / Sep - Dec 2005 Drugs for Overactive Bladder Symptoms Download View
Issue 56 / Apr - Aug 2005 Drugs for Alzheimer's Disease Download View
Issue 55 / Jan - Mar 2005 Clinical Pearls from The Cochrane Library Download View
Issue 54 / Nov - Dec 2004 Use of Benzodiazepines in BC – Is it consistent with recommendations? Download View
Issue 53 / Jul - Oct 2004 Rofecoxib (Vioxx®) withdrawal generates uncertainty about COX-2s – Do product monographs adequately inform? Download View
Issue 52 / Apr - Jun 2004 Antidepressant Medications in Children and Adolescents Download View
Issue 51 / Jan - Mar 2004 New Drugs VIII – Telithromycin (Ketek®), Ezetimibe (Ezetrol®), Topical Pimecrolimus (Elidel®), and Tacrolimus (Protopic®) Download View
Issue 50 / Oct - Dec 2003 Can blood pressure be lowered by a change in diet? Evidence from the DASH trials Download View
Issue 49 / Jul - Sep 2003 Statin's benefit for secondary prevention confirmed. What is the optimal dosing strategy? Download View
Issue 48 / Apr - Jun 2003 Do Statins have a Role in Primary Prevention? Download View
Issue 47 / Jan - Mar 2003 The Answer: Thiazides First-line for Hypertension Download View
Issue 46 / Oct - Dec 2002 Menopausal Combined Hormone Therapy Update Download View
Issue 45 / Jun - Sep 2002 Do Single Stereoisomer Drugs Provide Value? Download View
Issue 44 / Feb - May 2002 New Drugs VII – Mirtazapine (Remeron®), Salmon-Calcitonin Nasal Spray (Miacalcin®), Gatifloxacin (Tequin®), Moxifloxacin Download View
Issue 43 / Nov - Jan 2002 COX-2 inhibitors update: Do journal publications tell the full story? Download View
Issue 42 / Aug - Oct 2001 Serious Adverse Event Analysis: Lipid-Lowering Therapy Revisited Download View
Issue 41 / May - Jul 2001 Asymptomatic Bacteriuria in Pregnancy: Rapid answers using the Cochrane Library Download View
Issue 40 / Mar - Apr 2001 Direct To Consumer Advertising: Finasteride for male pattern hair loss Download View
Issue 39 / Jan - Feb 2001 Selective COX-2 inhibitors: Are they safer? Download View
Issue 38 / Nov - Dec 2000 Prevention and Treatment of Influenza A and B Download View
Issue 37 / Sep - Oct 2000 Antiplatelet Chemoprevention of Occlusive Vascular Events and Death Download View
Issue 36 / Jul - Aug 2000 New Drugs VI – Rosiglitazone (Avandia®), Tolterodine (Detrol®), Bupropion (Wellbutrin SR®, Zyban®), Doxazosin (Cardura®) Download View
Issue 35 / May - Jun 2000 Sources of Drug Therapy Information Download View
Issue 34 / Mar - Apr 2000 New Drugs V – Orlistat (Xenical®), Raloxifene (Evista®), Spironolactone (Aldactone®) Download View
Issue 33 / Jan - Feb 2000 Treatment of Pain in the Older Patient Download View
Issue 32 / Oct - Nov 1999 Management of Erectile Dysfunction Download View
Issue 31 / Aug - Sep 1999 Celecoxib (Celebrex®) – Is it a Breakthrough Drug? Download View
Issue 30 / Jun - Jul 1999 Levels of Evidence for Clinical Decisions: Menopausal Hormone Therapy Revisited Download View
Issue 29 / Apr - May 1999 LEUKOTRIENE ANTAGONISTS: What is their role in the management of ASTHMA? Download View
Issue 28 / Jan - Mar 1999 Angiotensin II Receptor Blockers – Their role in hypertension and congestive heart failure Download View
Issue 27 / Nov - Dec 1998 REVIEW & UPDATE 1998: Hypertension, Type 2 Diabetes, Lipid Lowering Therapy, Olanzapine Download View
Issue 26 / May - Jun 1998 New Drugs IV – Donepezil (Aricept®), Levofloxacin (Levaquin®), Pantoprazole (Pantoloc®), Quetiapine (Seroquel®) Download View
Issue 25 / Jun - Aug 1998 Herbal Medicines – An Evidence Based Look Download View
Issue 24 / Apr - May 1998 LIPID LOWERING THERAPY Download View
Issue 23 / Jan - Mar 1998 MANAGEMENT OF TYPE 2 DIABETES Download View
Issue 22 / Nov - Dec 1997 Treatment of Acute Migraine Headaches Download View
Issue 21 / Sep - Oct 1997 Effective Clinical Tobacco Intervention Download View
Issue 20 / Jul - Aug 1997 New Drugs III – Alendronate (Fosamax®), Dorzolamide (Trusopt®), Acarbose (Prandase®), Olanzapine (Zyprexa®) Download View
Issue 19 / May - Jun 1997 Medical Management of Benign Prostatic Hyperplasia Download View
Issue 18 / Feb - Apr 1997 Management of Anxiety Disorders in Primary Care Download View
Issue 17 / Jan 1997 New Drugs – Famciclovir (Famvir®) and Valacyclovir (Valtrex®), Torsemide (Demadex®), Etodolac (Ultradol®), Naltrexone Download View
Issue 16 / Jan - Feb 1996 Review and Update 1996 Download View
Issue 15 / Aug - Oct 1996 Evidence Based Drug Therapy – What Do the Numbers Mean? Download View
Issue 14 / May - Jul 1996 Menopausal Hormone Therapy Download View
Issue 13 / Mar - Apr 1996 New Drugs I – Losartan (Cozaar®), Lansoprazole (Prevacid®), Cefprozil (Cefzil®), Zuclopenthixol (Clopixol®) Download View
Issue 12 / Jan - Feb 1996 Changing Concepts in the Management of Asthma Download View
Issue 11 / Nov - Dec 1995 To Sleep or Not to Sleep: Here Are Your Questions Download View
Issue 10 / Oct 1995 Dose Titration: Minimize to Maximize Download View
Issue 9 / Sep 1995 Review and Update 1995 Download View
Issue 8 / Jul - Aug 1995 Drugs of Choice in the Treatment of Hypertension (Part 2) Download View
Issue 7 / Jun 1995 Drugs of Choice in the Treatment of Hypertension (Part 1) Download View
Issue 6 / May 1995 Medical Management of Ischemic Heart Disease: the Optimal Use of Nitrates Download View
Issue 5 / Mar 1995 Anti-infective Guidelines for Community-Acquired Infections Download View
Issue 4 / Feb 1995 Should We Be Using NSAIDs for the Treatment of Osteoarthritis and "Rheumatism"? Download View
Issue 3 / Dec 1994 Treatment of Gastroesophageal Reflux Disease (GERD) Download View
Issue 2 / Nov 1994 Definitive Treatment of Peptic Ulcer Disease by Eradication of Helicobacter Pylori (H.pylori) Download View
Issue 1 / Oct 1994 Treatment of Non-Ulcer Dyspepsia in Adults: Common Questions about H2-blockers Download View