The Women's Health Initiative (WHI) trial is a striking example of how scientific evidence can improve prescribing practice.1 Therapeutics Letter 30 reviewed the evidence on hormone replacement therapy in 1999. Evidence then available showed that...
Schneeweiss S, Maclure M, Dormuth C, Avorn J Link to publication...
Stereoisomers are molecules with one or more “chiral” centres that allow the possibility of forms with the same chemical formula but differing spatial arrangements. Quinidine and quinine are a naturally occurring pair of stereoisomers, which...
Mirtazapine (Remeron®) Approved indication: “Symptomatic relief of depressive illness.” 1 Mechanism of action: As with all antidepressants the mechanism of therapeutic benefit is unknown. It is an inhibitor of a number of receptors including adrenergic, serotonergic, histaminic and muscarinic....