On his show the Human Upgrade, Dave Asprey talks with Dr. John Abramson about his new book Sickening: How Big Pharma Broke American Health Care and How We Can Repair It." This entertaining podcast interview discusses the...
Some prescribers “titrate” patients to high “target” doses of cyclobenzaprine, duloxetine, gabapentin or pregabalin; and some guidelines advocate progressive dose increases.1-3 Whether intended to minimize adverse effects, or to improve pain relief, this approach is...
In this presentation, Tom Stanley shows how excess statistical significance (ESS) can improve the credibility of research synthesis. This generalizes on the notion of an excess of statistical significance by Ioannidis & Trikalinos’ (2007) that...
Anat Fisher, Jason D. Kim, Colin R. Dormuth CMAJ Open February 15, 2022 10 (1) E109-E118; DOI: 10.9778/cmajo.20200319 Abstract Background: In 2019, British Columbia’s public drug plan, PharmaCare, was the first in Canada to implement a nonmedical switching...